Prognostic implications of the presence of FLT3 mutations in patients with acute myeloid leukemia.

doi:10.1080/1042819031000067503

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Article

Prognostic implications of the presence of FLT3 mutations in patients with acute myeloid leukemia.

Leukemia & lymphoma - 1 Jun 2003

Kottaridis Panagiotis D, Gale Rosemary E, Linch David C

Abstract excerpt

Several studies have shown that mutations in the FLT3 gene are common events in AML, with approximately one third of adult patients harbouring either an internal tandem duplication in the juxtramembrane domain or a D835 mutation in the kinase domain. The majority of studies in pediatric and adult...

Topics

Adult
Gene Frequency
Humans
Leukemia, Myeloid, Acute
Middle Aged
Mutation
Prognosis
Proto-Oncogene Proteins
Receptor Protein-Tyrosine Kinases
Receptors, Cell Surface
Tandem Repeat Sequences
fms-Like Tyrosine Kinase 3

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