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Article

Epidemiological and biological evidence for a compensatory effect of connection domain mutation N348I on M184V in HIV-1 reverse transcriptase.

The Journal of infectious diseases - 1 Apr 2010

von Wyl Viktor, Ehteshami Maryam, Symons Jori, Bürgisser Philippe, Nijhuis Monique, Demeter Lisa M, Yerly Sabine, Böni Jürg, Klimkait Thomas, Schuurman Rob, Ledergerber Bruno, Götte Matthias, Günthard Huldrych F

Abstract excerpt

BACKGROUND: The connection domain mutation N348I confers resistance to zidovudine (AZT) and is associated with the lamivudine (3TC) mutation M184V. We explored the biochemical and virological influence of N348I in the context of M184V. METHODS: Genotypic resistance data for patients receiving mon...

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Share to DNA, Viral
Share to Drug Resistance, Multiple, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Therapy, Combination

Share to HIV Reverse Transcriptase

Share to Lamivudine

Share to Reverse Transcriptase Inhibitors

Share to Statistics, Nonparametric

Share to Zidovudine

Source

Identifiers

PMID: 20170373
DOI: 10.1086/651168

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20170373-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Epidemiological and biological evidence for a compensatory effect of connection domain mutation N348I on M184V in HIV-1 reverse transcriptase.PMID 20170373Read ↗

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