Nijmegen breakage syndrome gene (NBS1) is not the tumor suppressor gene at 8q21.3 involved in colorectal carcinoma.

Abstract excerpt

Genetic instability is characteristic of cancer cells, both at the chromosomal level (e.g., aneuploidy, aneusomy, translocations), and at the sequence level (e.g., microsatellite instability). Colorectal cancers (CRCs) can be divided into two groups: tumors of the proximal colon, where microsatellite instability is frequent and chromosomal aberrations are rare, and tumors of the distal colon, where microsatellite...

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