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Article

Increased cancer risk of heterozygotes with NBS1 germline mutations in Poland.

International journal of cancer - 10 Aug 2004

Steffen Jan, Varon Raymonda, Mosor Maria, Maneva Galina, Maurer Martin, Stumm Markus, Nowakowska Dorota, Rubach Maryna, Kosakowska Ewa, Ruka Włodzimierz, Nowecki Zbigniew, Rutkowski Piotr, Demkow Tomasz, Sadowska Małgorzata, Bidziński Mariusz, Gawrychowski Krzysztof, Sperling Karl

Abstract excerpt

It has been suggested based on familial data that Nijmegen breakage syndrome (NBS) heterozygotes have an increased risk of malignant tumors. We found 15 carriers of the 657del5 mutation and 8 carriers of the R215W molecular variant of the NBS1 gene among 1,289 consecutive patients from Central Poland with various cancers and only 10 and 4 such carriers, respectively, in 1,620 controls from this region. Most of...

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Identifiers

PMID: 15185344
DOI: 10.1002/ijc.20239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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