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Article

Cancer risk of heterozygotes with the NBN founder mutation.

Journal of the National Cancer Institute - 19 Dec 2007

Seemanová Eva, Jarolim Petr, Seeman Pavel, Varon Raymonda, Digweed Martin, Swift Michael, Sperling Karl

Abstract excerpt

BACKGROUND: The autosomal recessive chromosomal instability disorder Nijmegen breakage syndrome (NBS) is associated with increased risk of lymphoid malignancies and other cancers. Cells from NBS patients contain many double-stranded DNA breaks. More than 90% of NBS patients are homozygous for a f...

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Identifiers

PMID: 18073374
DOI: 10.1093/jnci/djm251

Genes

NBN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18073374-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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