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Article

Allelic imbalance at NBS1 is frequent in both proximal and distal colorectal carcinoma.

Oncology reports - 1 Jan 2000

Uhrhammer N, Bay J O, Gosse-Brun S, Kwiatkowski F, Rio P, Daver A, Bignon Y J

Abstract excerpt

Nijmegen breakage syndrome (NBS) is a hereditary disorder involving chromosomal instability, cancer risk and radiosensitivity. NBS carriers have an increased risk of cancer, though the significance of mutations in the NBS1 gene in sporadic cancer has not yet been investigated. Because the loss of NBS1 is associated with increased chromosomal re-arrangements, and tumors of the colon are particularly prone to...

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Identifiers

PMID: 10671697
DOI: 10.3892/or.7.2.427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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