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Article

IRS4, a novel modulator of BMP/Smad and Akt signalling during early muscle differentiation

14 Aug 2017

Abstract excerpt

Elaborate regulatory networks of the Bone Morphogenetic Protein (BMP) pathways ensure precise signalling outcome during cell differentiation and tissue homeostasis. Here, we identified IRS4 as a novel regulator of BMP signal transduction and provide molecular insights how it integrates into the signalling pathway. We found that IRS4 interacts with the BMP receptor BMPRII and specifically targets Smad1 for...

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PMID: 28821740
DOI: 10.1038/s41598-017-08676-6

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