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Article

Loss of intercellular adhesion activates a transition from low- to high-grade human squamous cell carcinoma.

International journal of cancer - 15 Feb 2006

Margulis Alexander, Zhang Weitian, Alt-Holland Addy, Pawagi Sujata, Prabhu Padmaja, Cao Jian, Zucker Stanley, Pfeiffer Laurence, Garfield Jacqueline, Fusenig Norbert E, Garlick Jonathan A

Abstract excerpt

The relationship between loss of intercellular adhesion and the biologic properties of human squamous cell carcinoma is not well understood. We investigated how abrogation of E-cadherin-mediated adhesion influenced the behavior and phenotype of squamous cell carcinoma in 3D human tissues. Cell-cell adhesion was disrupted in early-stage epithelial tumor cells (HaCaT-II-4) through expression of a dominant-negative...

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PMID: 16152579
DOI: 10.1002/ijc.21409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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