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Article

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila.

Neuron - 16 May 2002

Jackson George R, Wiedau-Pazos Martina, Sang Tzu-Kang, Wagle Naveed, Brown Carlos A, Massachi Sasan, Geschwind Daniel H

Abstract excerpt

Pathologic alterations in the microtubule-associated protein tau have been implicated in a number of neurodegenerative disorders, including Alzheimer's disease (AD), progressive supranuclear palsy (PSP), and frontotemporal dementia (FTD). Here, we show that tau overexpression, in combination with phosphorylation by the Drosophila glycogen synthase kinase-3 (GSK-3) homolog and wingless pathway component (Shaggy),...

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PMID: 12062036
DOI: 10.1016/s0896-6273(02)00706-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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