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Article

The stress-response factor SigH modulates the interaction between Mycobacterium tuberculosis and host phagocytes.

PloS one - 1 Jan 2012

Dutta Noton K, Mehra Smriti, Martinez Alejandra N, Alvarez Xavier, Renner Nicole A, Morici Lisa A, Pahar Bapi, Maclean Andrew G, Lackner Andrew A, Kaushal Deepak

Abstract excerpt

The Mycobacterium tuberculosis stress response factor SigH plays a crucial role in modulating the pathogen's response to heat, oxidative-stress, envelope damage and hypoxia. We hypothesized that the lack of this key stress response factor would alter the interaction between the pathogen and its host cells. We compared the interaction of Mtb, Mtb:Δ-sigH and a strain where the mutation had been genetically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22235255
DOI: 10.1371/journal.pone.0028958
PMCID: PMC3250399

Genes

PTGS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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