Article
Improved detection of small deletions in complex pools of DNA.
Nucleic acids research - 15 Jun 2002
Edgley Mark, D'Souza Anil, Moulder Gary, McKay Sheldon, Shen Bin, Gilchrist Erin, Moerman Donald, Barstead Robert
Abstract excerpt
About 40% of the genes in the nematode Caenorhabditis elegans have homologs in humans. Based on the history of this model system, it is clear that the application of genetic methods to the study of this set of genes would provide important clues to their function in humans. To facilitate such genetic studies, we are engaged in a project to derive deletion alleles in every gene in this set. Our standard methods...
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