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Article

Parallel genetics of regulatory sequences using scalable genome editing in vivo.

Cell reports - 13 Apr 2021

Froehlich Jonathan J, Uyar Bora, Herzog Margareta, Theil Kathrin, Glažar Petar, Akalin Altuna, Rajewsky Nikolaus

Abstract excerpt

How regulatory sequences control gene expression is fundamental for explaining phenotypes in health and disease. Regulatory elements must ultimately be understood within their genomic environment and development- or tissue-specific contexts. Because this is technically challenging, few regulatory elements have been characterized in vivo. Here, we use inducible Cas9 and multiplexed guide RNAs to create hundreds...

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PMID: 33852857
DOI: 10.1016/j.celrep.2021.108988

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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