Article
Use of SNPs to determine the breakpoints of complex deficiencies, facilitating gene mapping in Caenorhabditis elegans.
BMC genetics - 26 May 2005
Kadandale Pavan, Geldziler Brian, Hoffmann Melissa, Singson Andrew
Abstract excerpt
BACKGROUND: Genetic deletions or deficiencies have been used for gene mapping and discovery in various organisms, ranging from the nematode Caenorhabditis elegans all the way to humans. One problem with large deletions is the determination of the location of their breakpoints. This is exacerbated in the case of complex deficiencies that delete a region of the genome, while retaining some of the intervening...
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