Article
Rapid compensation for glycosylphosphatidylinositol anchor deficient keratinocytes after birth: visualization of glycosylphosphatidylinositol-anchored proteins in situ.
The Journal of investigative dermatology - 1 Jun 2002
Gao Xing-Hua, Kondoh Gen, Tarutani Masahito, Hara Mariko, Inoue Shintaro, Nakanishi Tomoko, Okabe Masaru, Yamaguchi Yuji, Yoshikawa Kunihiko, Itami Satoshi, Takeda Junji
Abstract excerpt
Pig-a, an X-linked gene, is a key component of glycosylphosphatidylinositol (GPI) anchor biosynthesis based on the fact that lack of this gene causes deficiencies of hundreds of GPI-anchored proteins. We previously demonstrated an essential role for the GPI-anchor in keratinocyte differentiation using male Pig-a knockout mice (K5-Cre:Pig-a flox). Here we analyzed keratinocytes of the female K5-Cre: Pig-a flox/+...
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