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Article

X inactivation and somatic cell selection rescue female mice carrying a <i>Piga</i> -null mutation

22 Jun 1999

Abstract excerpt

A somatic mutation in the X linked PIGA gene is responsible for the deficiency of glycosyl phosphatidylinositol (GPI)-anchored proteins on blood cells from patients with paroxysmal nocturnal hemoglobinuria. No inherited form of GPI-anchor deficiency has been described. Because conventional Piga gene knockout is associated with high embryonic lethality in chimeric mice, we used the Cre/loxP system. We generated...

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PMID: 10377440
DOI: 10.1073/pnas.96.13.7479

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