Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic and functional characterization of a mouse model of targeted Pig-a deletion in hematopoietic cells.

Haematologica - 1 Feb 2010

Visconte Valeria, Raghavachari Nalini, Liu Delong, Keyvanfar Keyvan, Desierto Marie J, Chen Jichun, Young Neal S

Abstract excerpt

BACKGROUND: Somatic mutation in the X-linked phosphatidylinositol glycan class A gene (PIG-A) causes glycosyl phosphatidylinositol anchor deficiency in human patients with paroxysmal nocturnal hemoglobinuria. DESIGN AND METHODS: We produced an animal model of paroxysmal nocturnal hemoglobinuria by conditional Pig-a gene inactivation (Pig-a(-/-)) in hematopoietic cells; mice carrying two lox sites flanking exon 6...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Cells
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Gene Deletion

Share to Hemoglobinuria, Paroxysmal

Share to Membrane Proteins

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 19679885
DOI: 10.3324/haematol.2009.011650
PMCID: PMC2817023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic and functional characterization of a mouse model of targeted Pig-a deletion in hematopoietic cells.PMID 19679885Read ↗

Different roles of glycosylphosphatidylinositol in various hematopoietic cells as revealed by a mouse model of paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

Fes-Cre Targets Phosphatidylinositol Glycan Class a (Piga) Inactivation to Hematopoietic Stem Cells in the Bone MarrowSemantic proximity Read ↗

X inactivation and somatic cell selection rescue female mice carrying a <i>Piga</i> -null mutationSemantic proximity Read ↗

Paroxysmal nocturnal hemoglobinuria: new insights from murine Pig-a-deficient hematopoiesis.Semantic proximity Read ↗

Generation of glycosylphosphatidylinositol anchor protein-deficient blood cells from human induced pluripotent stem cells.Semantic proximity Read ↗

Increased sensitivity to complement and a decreased red blood cell life span in mice mosaic for a nonfunctional Piga gene.Semantic proximity Read ↗

Paroxysmal nocturnal hemoglobinuria: insights from recent advances in molecular biology.Semantic proximity Read ↗

PIG-A mutations in paroxysmal nocturnal hemoglobinuria and in normal hematopoiesis.Semantic proximity Read ↗

Abnormalities of PIG-A Transcripts in Granulocytes from Patients with Paroxysmal Nocturnal HemoglobinuriaSemantic proximity Read ↗

Role of phosphatidylinositol-linked proteins in paroxysmal nocturnal hemoglobinuria pathogenesis.Semantic proximity Read ↗

Paroxysmal nocturnal hemoglobinuria: An acquired genetic disease.Semantic proximity Read ↗

Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.