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Article

Oestrogen receptor gene variation is a determinant of coronary reactivity in healthy young men.

European journal of clinical investigation - 1 Jun 2002

Lehtimäki T, Laaksonen R, Mattila K M, Janatuinen T, Vesalainen R, Nuutila P, Laakso J, Jaakkola O, Koivula T, Knuuti J

Abstract excerpt

BACKGROUND: Oxidised low-density lipoprotein (ox-LDL) is a determinant of impaired coronary function and oestrogens inhibit its formation probably throughout genetically-variable oestrogen receptor 1 (ESR1) in artery wall. We hypothesized that the ESR1 polymorphism might influence coronary function and reactivity as measured by positron emission tomography (PET), which allows the detection of coronary dysfunction...

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Source

Identifiers

PMID: 12059984
DOI: 10.1046/j.1365-2362.2002.01010.x

Genes

ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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