Article
Genetic polymorphisms of estrogen receptors in patients with premature coronary artery disease.
Archives of medical research - 1 Jan 2000
Mansur Antonio de Padua, Nogueira Carlos César Montezino, Strunz Célia M C, Aldrighi José Mendes, Ramires José Antonio F
Abstract excerpt
BACKGROUND: Estrogen protects against atherosclerosis through its genomic/nongenomic effects. Estrogen receptors (ESR) alpha (1) and beta (2) mediate much estrogen action. Both receptors exist in the arterial wall, but the extent of their distribution in arterial layers is unknown. Allelic variants of the gene encoding ESR1 and ESR2 may alter their expression and function, resulting in genetic variability....
Topics
- Adult
- Age Factors
- Apolipoproteins B
- Body Mass Index
- Case-Control Studies
- Coronary Artery Disease
- Estrogen Receptor alpha
- Estrogen Receptor beta
- Female
- Gene Frequency
- Genetic Predisposition to Disease