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Article

Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model.

The American journal of pathology - 1 Jun 2002

Shimokawa Isao, Higami Yoshikazu, Utsuyama Masanori, Tuchiya Tomoshi, Komatsu Toshimitsu, Chiba Takuya, Yamaza Haruyoshi

Abstract excerpt

The longer life span in dwarf mice suggests that a reduction in the growth hormone (GH)-insulin-like growth factor (IGF)-1 axis retards aging and extends the life span in mammals. We tested this hypothesis in a transgenic strain of rats whose GH gene was suppressed by an anti-sense GH transgene. Male rats homozygous for the transgene (tg/tg) had a reduced number of pituitary GH cells, a lower plasma concentration...

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Identifiers

PMID: 12057928
DOI: 10.1016/S0002-9440(10)61173-X
PMCID: PMC1850833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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