Article
Animal models of human mitochondrial DNA mutations.
Biochimica et biophysica acta - 1 May 2012
Dunn David A, Cannon Matthew V, Irwin Michael H, Pinkert Carl A
Abstract excerpt
BACKGROUND: Mutations in mitochondrial DNA (mtDNA) cause a variety of pathologic states in human patients. Development of animal models harboring mtDNA mutations is crucial to elucidating pathways of disease and as models for preclinical assessment of therapeutic interventions. SCOPE OF REVIEW: This review covers the knowledge gained through animal models of mtDNA mutations and the strategies used to produce...
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