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Article

Allotopic expression of ATP6 in the mouse as a transgenic model of mitochondrial disease.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015

Dunn David A, Pinkert Carl A

Abstract excerpt

Progress in animal modeling of polymorphisms and mutations in mitochondrial DNA (mtDNA) is not as developed as nuclear transgenesis due to a host of cellular and physiological distinctions. mtDNA mutation modeling is of critical importance as mutations in the mitochondrial genome give rise to a variety of pathological conditions and play a contributing role in many others. Nuclear localization and transcription...

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PMID: 25634280
DOI: 10.1007/978-1-4939-2288-8_18

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