Article
Localization of genes that control LDL size fractions in baboons.
Atherosclerosis - 1 May 2003
Rainwater David L, Kammerer Candace M, Mahaney Michael C, Rogers Jeffrey, Cox Laura A, Schneider Jennifer L, VandeBerg John L
Abstract excerpt
LDL phenotypes are strongly associated with risk of cardiovascular disease and are heritable, although little is known about individual genes that influence them. We investigated genetic control of LDL size-related phenotypes in 634 pedigreed baboons fed three diets contrasting in levels of fat and cholesterol. On a high-cholesterol high-fat diet, we obtained significant evidence for a quantitative trait locus...
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