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Article

Hsp90 as a capacitor of phenotypic variation.

Nature - 6 Jun 2002

Queitsch Christine, Sangster Todd A, Lindquist Susan

Abstract excerpt

Heat-shock protein 90 (Hsp90) chaperones the maturation of many regulatory proteins and, in the fruitfly Drosophila melanogaster, buffers genetic variation in morphogenetic pathways. Levels and patterns of genetic variation differ greatly between obligatorily outbreeding species such as fruitflies and self-fertilizing species such as the plant Arabidopsis thaliana. Also, plant development is more plastic, being...

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PMID: 12050657
DOI: 10.1038/nature749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Hsp90 as a capacitor of phenotypic variation.PMID 12050657Read ↗

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Hsp90 as a capacitor for morphological evolution.Semantic proximity Read ↗

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The Hsp90 capacitor, developmental remodeling, and evolution: the robustness of gene networks and the curious evolvability of metamorphosis.Semantic proximity Read ↗

Modularity and intrinsic evolvability of Hsp90-buffered change.Semantic proximity Read ↗

Hsp90 and developmental networks.Semantic proximity Read ↗

HSP90-buffered genetic variation is common in Arabidopsis thaliana.Semantic proximity Read ↗

Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution.Semantic proximity Read ↗

Hsp90 is important for fecundity, longevity, and buffering of cryptic deleterious variation in wild fly populations.Semantic proximity Read ↗

Control of canalization and evolvability by Hsp90.Semantic proximity Read ↗

Phenotypic diversity and altered environmental plasticity in Arabidopsis thaliana with reduced Hsp90 levels.Semantic proximity Read ↗

HSP90 buffers newly induced mutations in massively mutated plant linesSemantic proximity Read ↗

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