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Article

Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 2002

Tsuruyama Tatsuaki, Nakamura Takuro, Jin Guang, Ozeki Munetaka, Yamada Yoshihiro, Hiai Hiroshi

Abstract excerpt

We found that the second intron of Stat5a was one of the common integration sites of the endogenous ecotropic murine leukemia virus, i.e., SL/Kh virus integration-1 (Svi1), in early pre-B lymphomas in SL/Kh mice. The high expression of STAT5A induced by Svi1 integration and activation accelerated the transcription of its target genes such as c-Myc. Transfection of the constitutively active Stat5a mutant cDNA, but...

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Identifiers

PMID: 12048235
DOI: 10.1073/pnas.112202899
PMCID: PMC123054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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