Article
Svi3: A provirus common integration site in c-myc in SL/Kh pre-B lymphomas.
Cancer science - 1 Sept 2003
Jin Guang, Tsuruyama Tatsuaki, Yamada Yoshihiro, Hiai Hiroshi
Abstract excerpt
Spontaneous pre-B lymphomas in SL/Kh mice occur by somatic acquisition of a provirus genome of endogenous murine leukemia virus (MuLV). Inverse PCR amplification and sequence analyses of a provirus and its host flanking fragment revealed a proviral insertion into c-myc in 3 out of 60 SL/Kh pre-B lymphomas, named Svi3 lymphomas (SL/Kh virus integration site-3). Southern blot analysis revealed that two lymphomas...
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