Increased lymphomagenicity and restored disease specificity of AML1 site (core) mutant SL3-3 murine leukemia virus by a second-site enhancer variant evolved in vivo.

Abstract excerpt

SL3-3 is a highly T-lymphomagenic murine retrovirus. The major genetic determinant of disease is the transcriptional enhancer, which consists of a repeated region with densely packed binding sites for several transcription factors, including AML1 (also known as core binding factor and polyoma enh...

Topics

• Animals
• Base Sequence
• Binding Sites
• Core Binding Factor Alpha 2 Subunit
• DNA-Binding Proteins
• Enhancer Elements, Genetic
• Genetic Variation
• Leukemia Virus, Murine
• Lymphoma
• Mice
• Mice, Inbred Strains
• Molecular Sequence Data
• Neurofibromin 1
• Proteins
• Proto-Oncogene Proteins