Article
Mannose-binding lectin gene, MBL2, polymorphisms are not associated with susceptibility to invasive pneumococcal disease in children.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Aug 2014
Lundbo Lene Fogt, Harboe Zitta Barrella, Clausen Louise Nygaard, Hollegaard Mads Vilhelm, Sørensen Henrik Toft, Hougaard David Michael, Konradsen Helle Bossen, Nørgaard Mette, Benfield Thomas
Abstract excerpt
BACKGROUND: Most children are transiently colonized with Streptococcus pneumoniae, but very few develop invasive pneumococcal disease (IPD). Host genetic variation of innate immunity may predispose to IPD. We investigated the effect of genetic variation in the mannose-binding lectin gene, MBL2, on susceptibility and disease severity of IPD in previously healthy children aged <5 years. METHODS: IPD cases were...
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