Article
Mutant p53 expression and apoptotic activity of Helicobacter pylori positive and negative gastritis in correlation with the presence of intestinal metaplasia.
European journal of gastroenterology & hepatology - 1 Apr 2003
Unger Zsuzsa, Molnár Béla, Prónai László, Szaleczky Erika, Zágoni Tamás, Tulassay Zsolt
Abstract excerpt
BACKGROUND: Mutation of the p53 gene is detectable in most cases of gastric cancer, as it is the most common genetic alteration in human malignancies. It is also well documented that Helicobacter pylori infection plays an important role in gastric carcinogenesis. There is still no clarification, however, concerning how genetic instability influences the homeostasis of gastric epithelium. We have studied the...
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