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Polyomavirus large T antigens: Unraveling a complex interactome

13 Dec 2024

Abstract excerpt

All members of the polyomavirus family encode a large T antigen (LT) protein that plays essential roles in viral DNA replication, regulation of viral gene expression, and the manipulation of numerous cellular pathways. Over 100 polyomaviruses have been discovered in hosts ranging from arthropods and fish to mammals, including fourteen that infect humans. LT is among the most studied viral proteins with thousands...

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PMID: 39675526
DOI: 10.1016/j.tvr.2024.200306

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