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Human Polyomaviruses: The Battle of Large and Small Tumor Antigens

1 Jan 2017

Abstract excerpt

About 40 years ago, the large and small tumor antigens (LT-Ag and sT-Ag) of the polyomavirus (PyVs) simian vacuolating virus 40 have been identified and characterized. To date, it is well known that all the discovered human PyVs (HPyVs) encode these 2 multifunctional and tumorigenic proteins, expressed at viral replication early stage. The 2 T-Ags are able to transform cells both in vitro and in vivo and seem to...

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PMID: 29238174
DOI: 10.1177/1178122x17744785

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