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Article

Reduced anxiety in the mice expressing mutant (N141I) presenilin 2.

Journal of neuroscience research - 1 Feb 2009

Yuk Dong Yeon, Lee Yong Kyung, Nam Sang Yoon, Yun Young Won, Hwang Dae Youn, Choi Dong Young, Oh Ki Wan, Hong Jin Tae

Abstract excerpt

Alzheimer's disease (AD) is characterized by progressive cognitive impairment. The effect of presenilin 1 (PS1) and PS2 mutation on cognition has been well characterized in a variety of transgenic mice. However, noncognitive behaviors have not been considered in these mice. In the present study, we found that transgenic mice expressing mutant PS2 (N141I) displayed decreased anxiety behavior determined by the...

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Source

Identifiers

PMID: 18803281
DOI: 10.1002/jnr.21861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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