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Article

Aberrant expressions of pathogenic phenotype in Alzheimer's diseased transgenic mice carrying NSE-controlled APPsw.

Experimental neurology - 1 Mar 2004

Hwang Dae Y, Cho Jung S, Lee Su H, Chae Kab R, Lim Hwa J, Min Sea H, Seo Su J, Song Youn S, Song Chi W, Paik Sang G, Sheen Yhun Y, Kim Yong K

Abstract excerpt

Mutations in the APP gene lead to enhanced cleavage by the beta- and gamma-secretase, and increased Abeta formation, which are tightly associated with Alzheimer's disease (AD)-like neuropathological changes. To examine whether depositions of Abeta by APP mutations are increased, and if this is as...

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Source

Identifiers

PMID: 14980807
DOI: 10.1016/j.expneurol.2003.09.021

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14980807-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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