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Article

Alzheimer's phenotypes induced by overexpression of human presenilin 2 mutant proteins stimulate significant changes in key factors of glucose metabolism.

Molecular medicine reports - 1 May 2013

Lee Young Ju, Kim Ji Eun, Hwang In Sik, Kwak Moon Hwa, Lee Jae Ho, Jung Young Jin, An Beum Soo, Kwon Hyeog Soong, Kim Byoung Chul, Kim Seon Jong, Kim Joo Man, Hwang Dae Youn

Abstract excerpt

Alzheimer's disease (AD) is closely associated with significant defects in glucose metabolism. To investigate whether AD pathology induced by overexpression of human mutant presenilin 2 (PS2) protein induces changes in glucose metabolism, glucose‑related factors were analyzed in the brain of 12‑month‑old neuron‑specific enolase (NSE)/hPS2m transgenic (Tg) mice. NSE/hPS2m Tg mice used in this study showed AD‑like...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23546527
DOI: 10.3892/mmr.2013.1404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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