Article
Effect of germ-line genetic variation on breast cancer survival in a population-based study.
Cancer research - 1 Jun 2002
Goode Ellen L, Dunning Alison M, Kuschel Bettina, Healey Catherine S, Day Nicholas E, Ponder Bruce A J, Easton Douglas F, Pharoah Paul P D
Abstract excerpt
Somatic genetic alterations in tumors are known to correlate with survival, but little is known about the prognostic significance of germ-line variation. We assessed the effect of germ-line variation on survival among women with breast cancer participating in a British population-based study. Up to 2430 cases for whom current vital status data were available were screened for BRCA1/2 mutations and genotyped for...
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