Transfer RNA determinants for translational editing by Escherichia coli valyl-tRNA synthetase.

doi:10.1093/nar/30.11.2538

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Article

Transfer RNA determinants for translational editing by Escherichia coli valyl-tRNA synthetase.

Nucleic acids research - 1 Jun 2002

Tardif Keith D, Horowitz Jack

Abstract excerpt

Valyl-tRNA synthetase (ValRS) has difficulty differentiating valine from structurally similar non-cognate amino acids, most prominently threonine. To minimize errors in aminoacylation and translation the enzyme catalyzes a proofreading (editing) reaction that is dependent on the presence of cognate tRNA(Val). Editing occurs at a site functionally distinct from the aminoacylation site of ValRS and previous results...

Topics

Acylation
Anticodon
Escherichia coli
Mutation
Protein Biosynthesis
RNA Editing
RNA, Bacterial
RNA, Transfer
RNA, Transfer, Val
Substrate Specificity
Threonine
Valine
Valine-tRNA Ligase

Source

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Identifiers

PMID: 12034843
DOI: 10.1093/nar/30.11.2538
PMCID: PMC117182

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