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Article

Transfer RNA determinants for translational editing by Escherichia coli valyl-tRNA synthetase.

Nucleic acids research - 1 Jun 2002

Tardif Keith D, Horowitz Jack

Abstract excerpt

Valyl-tRNA synthetase (ValRS) has difficulty differentiating valine from structurally similar non-cognate amino acids, most prominently threonine. To minimize errors in aminoacylation and translation the enzyme catalyzes a proofreading (editing) reaction that is dependent on the presence of cognate tRNA(Val). Editing occurs at a site functionally distinct from the aminoacylation site of ValRS and previous results...

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Source

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Identifiers

PMID: 12034843
DOI: 10.1093/nar/30.11.2538
PMCID: PMC117182

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transfer RNA determinants for translational editing by Escherichia coli valyl-tRNA synthetase.PMID 12034843Read ↗

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Mutational unmasking of a tRNA-dependent pathway for preventing genetic code ambiguity.Semantic proximity Read ↗

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