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Article

Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277.

Nucleic acids research - 1 Jun 2002

Buzek Jiri, Latonen Leena, Kurki Sari, Peltonen Karita, Laiho Marikki

Abstract excerpt

Using a bio-oligo pull-down DNA-binding assay we investigated the binding capacity of endogenous, DNA damage-induced p53 in human diploid fibroblasts to several p53-responsive elements (REs) present in p53-regulated genes. During the course of p53 accumulation, we observed a decrease in p53 binding to the GADD45 but not to the p21(WAF1/CIP1) RE. Using mutated GADD45 sequences we show that this change is dependent...

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Identifiers

PMID: 12034820
DOI: 10.1093/nar/30.11.2340
PMCID: PMC117181

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Source receipt: pubmed, retrieved 7 Sept 2026.

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