Article
Sex stratification of an inflammatory bowel disease genome search shows male-specific linkage to the HLA region of chromosome 6.
European journal of human genetics : EJHG - 1 Apr 2002
Fisher Sheila A, Hampe Jochen, Macpherson Andrew J S, Forbes Alastair, Lennard-Jones John E, Schreiber Stefan, Curran Mark E, Mathew Christopher G, Lewis Cathryn M
Abstract excerpt
Inflammatory bowel disease (IBD) is a multifactorial disorder, with both genetic and environmental factors contributing to the two clinical phenotypes of Crohn's disease (CD) and ulcerative colitis (UC). The underlying genetic model is thought to involve multiple genes with complex interactions between disease loci, and the NOD2 gene on chromosome 16 has recently been identified as a CD susceptibility locus....
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