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Article

Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets.

Proceedings of the National Academy of Sciences of the United States of America - 28 May 2002

Rocca Bianca, Secchiero Paola, Ciabattoni Giovanni, Ranelletti Franco O, Catani Lucia, Guidotti Lia, Melloni Elisabetta, Maggiano Nicola, Zauli Giorgio, Patrono Carlo

Abstract excerpt

Cyclooxygenase (COX)-1 or -2 and prostaglandin (PG) synthases catalyze the formation of various PGs and thromboxane (TX) A(2). We have investigated the expression and activity of COX-1 and -2 during human megakaryocytopoiesis. We analyzed megakaryocytes from bone marrow biopsies and derived from thrombopoietin-treated CD34(+) hemopoietic progenitor cells in culture. Platelets were obtained from healthy donors and...

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Identifiers

PMID: 12032335
DOI: 10.1073/pnas.112202999
PMCID: PMC124306

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Source receipt: pubmed, retrieved 7 Sept 2026.

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