Article
Translational approaches to functional platelet production ex vivo.
Thrombosis and haemostasis - 1 Jan 2016
Balduini Alessandra, Di Buduo Christian A, Kaplan David L
Abstract excerpt
Platelets, which are released by megakaryocytes, play key roles in haemostasis, angiogenesis, immunity, tissue regeneration and wound healing. The scarcity of clinical cures for life threatening platelet diseases is in a large part due to limited insight into the mechanisms that control the developmental process of megakaryocytes and the mechanisms that govern the production of platelets within the bone marrow....
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