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Article

Detecting natural selection at the molecular level: a reexamination of some "classic" examples of adaptive evolution.

Journal of molecular evolution - 1 Feb 2006

Nunney Leonard, Schuenzel Erin L

Abstract excerpt

An important criterion used to detect adaptive evolution in DNA sequence data is omega(i) > 1, where omega(i) is the ratio of nonsynonymous to synonymous substitution rates in lineage i. However, the evaluation of multiple omega(i) within a phylogenetic tree can easily inflate the statistical type I error rate. We developed two rigorous methods of analysis that avoid this and other potential pitfalls. We applied...

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PMID: 16416019
DOI: 10.1007/s00239-004-0334-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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