Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Telomere length deregulation and enhanced sensitivity to genotoxic stress in Arabidopsis mutants deficient in Ku70.

The EMBO journal - 3 Jun 2002

Riha Karel, Watson J Matthew, Parkey Jeffrey, Shippen Dorothy E

Abstract excerpt

The Ku70/80 heterodimer is a critical component of the non-homologous end-joining (NHEJ) pathway and of the telomere cap in yeast and mammals. We report the molecular characterization of the KU70 and KU80 genes in Arabidopsis and describe the consequences of a Ku70 deficiency. Arabidopsis KU70/80 genes are ubiquitously expressed and their products form stable heterodimers in vitro. Plants harboring a T-DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Telomere
Share to Antigens, Nuclear
Share to Dimerization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Helicases

Share to Ku Autoantigen

Share to Methyl Methanesulfonate

Share to Mutagens

Share to RNA, Complementary

Source

Open in PubMed Open full text

Identifiers

PMID: 12032094
DOI: 10.1093/emboj/21.11.2819
PMCID: PMC126030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Telomere length deregulation and enhanced sensitivity to genotoxic stress in Arabidopsis mutants deficient in Ku70.PMID 12032094Read ↗

Ku80 plays a role in non-homologous recombination but is not required for T-DNA integration in Arabidopsis.Semantic proximity Read ↗

Increased telomere length and hypersensitivity to DNA damaging agents in an Arabidopsis KU70 mutant.Semantic proximity Read ↗

Disruption of the Arabidopsis AtKu80 gene demonstrates an essential role for AtKu80 protein in efficient repair of DNA double-strand breaks in vivo.Semantic proximity Read ↗

Telomerase dependence of telomere lengthening in Ku80 mutant Arabidopsis.Semantic proximity Read ↗

Ku is required for telomeric C-rich strand maintenance but not for end-to-end chromosome fusions in Arabidopsis.Semantic proximity Read ↗

Genome stability in Arabidopsis cells exhibiting alternative lengthening of telomeres.Semantic proximity Read ↗

OsKu70 is associated with developmental growth and genome stability in rice.Semantic proximity Read ↗

Molecular analysis of telomere fusions in Arabidopsis: multiple pathways for chromosome end-joining.Semantic proximity Read ↗

Ku suppresses formation of telomeric circles and alternative telomere lengthening in Arabidopsis.Semantic proximity Read ↗

Characterization of gamma irradiation-induced mutations in Arabidopsis mutants deficient in non-homologous end joining.Semantic proximity Read ↗

Telomere dynamics and fusion of critically shortened telomeres in plants lacking DNA ligase IV.Semantic proximity Read ↗

Noncanonical functions of Ku may underlie essentiality in human cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.