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Human insulin gene is a target gene of hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-1beta.

Biochemical and biophysical research communications - 24 Sept 1999

Okita K, Yang Q, Yamagata K, Hangenfeldt K A, Miyagawa J, Kajimoto Y, Nakajima H, Namba M, Wollheim C B, Hanafusa T, Matsuzawa Y

Abstract excerpt

Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes characterized by autosomal dominant inheritance, early-onset, and impaired insulin secretion. The type 3 and type 5 forms of MODY result from mutations in the genes encoding the transcription factor, hepatocyte nuclear factor (HNF)-1alpha and HNF-1beta, respectively. The mechanism by which mutations in one allele of the HNF-1 gene impair...

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Identifiers

PMID: 10491332
DOI: 10.1006/bbrc.1999.1412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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