Article
Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements.
The Biochemical journal - 1 Jan 2005
Cagen Lauren M, Deng Xiong, Wilcox Henry G, Park Edwards A, Raghow Rajendra, Elam Marshall B
Abstract excerpt
The enhanced synthesis of fatty acids in the liver and adipose tissue in response to insulin is critically dependent on the transcription factor SREBP-1c (sterol-regulatory-element-binding protein 1c). Insulin increases the expression of the SREBP-1c gene in intact liver and in hepatocytes cultur...
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