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Differential Roles of Insulin Receptor Substrates in Brown Adipocyte Differentiation

14 Feb 2004

Abstract excerpt

Insulin promotes adipocyte differentiation via a complex signaling network involving multiple insulin receptor substrates (IRSs). In cultured brown preadipocytes, expression of IRS-1 and IRS-2 mRNAs and proteins was at relatively high levels before and after differentiation into mature fat cells, while IRS-3 transcript was not detectable in preadipocytes but increased during the course of differentiation, and...

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PMID: 14966273
DOI: 10.1128/mcb.24.5.1918-1929.2004

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