Article
The RGM protein DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis elegans.
Development (Cambridge, England) - 1 Jul 2010
Tian Chenxi, Sen Debjeet, Shi Herong, Foehr Marisa L, Plavskin Yevgeniy, Vatamaniuk Olena K, Liu Jun
Abstract excerpt
The bone morphogenetic protein (BMP) signaling pathway regulates multiple developmental and homeostatic processes. Mutations in the pathway can cause a variety of somatic and hereditary disorders in humans. Multiple levels of regulation, including extracellular regulation, ensure proper spatiotemporal control of BMP signaling in the right cellular context. We have identified a modulator of the BMP-like Sma/Mab...
Topics
- Animals
- Bone Morphogenetic Proteins
- Caenorhabditis elegans
- Humans
- Membrane Proteins
- Mutation
- Neurons
- Protein Binding
- Proteins
- Signal Transduction