Article
Association study of novel human serotonin 5-HT(1B) polymorphisms with alcohol dependence in Taiwanese Han.
Biological psychiatry - 1 Jun 2002
Sun Hsiao Fang Sunny, Chang Yuh Terng, Fann Cathy Shen-Jang, Chang Ching Jui, Chen Yi Hsin, Hsu Yun Pung, Yu Wu Yang, Cheng Andrew Tai-Ann
Abstract excerpt
BACKGROUND: Abnormal serotonergic pathways are implicated in numerous neuropsychiatric disorders, such as depression, anxiety, migraine, substance abuse, and alcoholism. The human serotonin receptor 1B, encoded by the HTR1B gene, is a presynaptic serotonin autoreceptor that plays a role in regulating serotonin synthesis and release. Because the linkage of antisocial alcoholism to the HTR1B gene was recently...
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