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Article

A haplotype analysis is consistent with the role of functional HTR1B variants in alcohol dependence.

Drug and alcohol dependence - 1 Apr 2012

Contini Verônica, Bertuzzi Guilherme P, Polina Evelise R, Hunemeier Tábita, Hendler Elisa M, Hutz Mara H, Bau Claiton H D

Abstract excerpt

BACKGROUND: Animal and human studies have suggested that the serotonergic system plays an important role in alcohol consumption and abuse, mainly due to the serotonin receptor 1B (5-HT(1B)) function in the mesolimbic reward pathway. Association studies between the HTR1B gene variants and alcoholism have found significant results. There is also evidence for a complex balancing regulation of the gene by two...

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Source

Identifiers

PMID: 22005095
DOI: 10.1016/j.drugalcdep.2011.09.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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