Article
Change from the CYP2D6 extensive metabolizer to the poor metabolizer phenotype during treatment With bupropion.
Therapeutic drug monitoring - 1 Jun 2002
Güzey Cüneyt, Norström Ake, Spigset Olav
Abstract excerpt
Some data indicate that bupropion inhibits the cytochrome P-450 enzyme CYP2D6, but very little published data is available on the extent of this inhibition. The objective of the present study was to quantify this inhibition in a subject treated with bupropion for smoking cessation. Genotypically, the patient was a CYP2D6 homozygous extensive metabolizer (EM). His CYP2D6 phenotype was assessed using the test drug...
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