Article
Cytochrome P450 2D6 genotype and methadone steady-state concentrations.
Journal of clinical psychopharmacology - 1 Apr 2001
Eap C B, Broly F, Mino A, Hämmig R, Déglon J J, Uehlinger C, Meili D, Chevalley A F, Bertschy G, Zullino D, Kosel M, Preisig M, Baumann P
Abstract excerpt
A genetic polymorphism of cytochrome P450 2D6 has been described with the existence of poor (zero functional genes), extensive (one or two functional genes), and ultrarapid metabolizers (three or more functional genes). The authors measured the steady-state trough (R)- (i.e., the active enantiomer), (S)-, and (R,S)-methadone plasma levels in opiate-dependent patients receiving methadone maintenance treatment...
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