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Article

Manipulation of early region 4.

Methods in molecular medicine - 1 Jan 2007

Boyer Julie, Ketner Gary

Abstract excerpt

Adenovirus early region 4 (E4) regulates processes in infected cells that include viral late gene expression, nonhomologous end joining, responses to DNA damage, and apoptosis. E4 is essential for viral growth in most cell lines. In this chapter, the current knowledge of the functions of six E4 products is summarized briefly. Protocols are presented for manipulation of E4, incorporation of E4 mutations into the...

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PMID: 17401160
DOI: 10.1385/1-59745-166-5:1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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